This type of weakness is often seen in people who have chronic fatigue syndrome, sleep disorders, depression, and chronic heart, lung, and kidney disease. The muscle isn't genuinely weaker, it can still do its job but it takes you more effort to manage it.
It is a sense of weariness or exhaustion that you feel when using the muscle. Both of these conditions result in weakened muscles which cannot move the usual load.
It is also seen in a condition called muscular dystrophy (discussed further below). It can happen, for example, following stroke. When this kind of weakness occurs the muscles are often floppier than usual and reduced in bulkiness. The muscle is not working properly - it has become abnormal. There is a reduction in the force which the muscle can exert, however hard you try. This shows itself as an inability to perform what you want to do with a muscle, even the first time you try.
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